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Immunohistochemical expression of P-cadherin and cortactin in oral squamous cell carcinomas

*Dena N. Mohammad, *Balkees T. Garib, **Hassanain H. Khudeir & *Ban A Abdul–Majeed

*College of Dentistry, University of Sulaimani

**College of Medicine, University of Baghdad



Objectives: to assess the expression and pattern distribution of P-cadherin and cortactin in OSCC, and to relate such expression to the histopathological grading.

Materials and Methods:
An immunohistochemical staining for P-cadherin and cortactin was performed on paraffin blocks of 40 oral squamous cell carcinoma and five normal mucosa. Fisher's exact test and Spearman's rank-order correlation were applied for analysis. P < 0.05 was considered statistically significant.

P-cadherin was either aberrantly cytoplasmic re-localized or lost in 45% of cases. 58.6% of positive cases were in grade I. Focal heterogeneous pattern was the commonest pattern (27.5%) and related to the degree of cell differentiation. The expression percentage was reported mainly in score 1 and 2 with no differences among histopathological grades (P=0.778). On the other hand, 70% of oral SCC had cytoplasmic cortactin expression. The majority of cases (85.7%) expressed diffuse pattern including all positive grade II and III cases. Nevertheless, statistical analysis did not reach a significant level (P= 0.722). Furthermore, no significant correlation was found between P-cadherin and cortactin expression.

Oral SCC had P-cadherin under-expression (focal) and cortactin over-expression (diffuse). The P-cadherin pattern distribution rather than expression percentage was related to the degree of cell differentiation. The expressions of these molecules were unrelated to each other.

Keywords: oral squamous cell carcinoma, P-cadherin, cortactin.


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