Issues‎ > ‎SDJ, Vol.4, No.1, 2017‎ > ‎


Anti-Inflammatory Effects of Prepared Punica Granatum Mouthwash on Patients with Moderate Gingivitis

*Chenar A. Mohammed, **Amal H. Aziz, **Shima G. Thanoon   Y

*   Department of Periodontics, College of Dentistry, Hawler Medical University, Erbil, Iraq.
** Department of Oral Diagnosis, College of Dentistry, Hawler Medical University, Erbil, Iraq.



Objective: Punica granatum is a herbal product used in the field of dentistry which has many potential effects including  bactericidal, antifungal, antiviral, and immune modulation. This study aimed to evaluate the effect of prepared Punica  granatum as an antiplaque and anti-inflammatory agent in the treatment of gingival inflammation. 

Methods: Sixty patients were enrolled in this study. Fourty five patients with moderate gingivitis were divided randomly into 3 groups; chlorhexidine group included 15 patients received once-daily dose of chlorhexidine mouthwash for 1 day, Punica I group included 15 patients received once-daily dose of Punica mouthwash for 1 day, and Punica II group included 15 patients received once-daily dose of Punica mouthwash for 2 consecutive days. Plaque index, gingival index, and bleeding on probing were assessed before rinsing and after 3 and 7 days of rinsing, also saliva were collected before rinsing and after 1 hour, 2 hrs, 1 and three days of rinsing to estimate the level of interleukine-1β. The rest 15 subjects were with clinically healthy gingiva. 

Results: Punica II group resulted in significant reduction of plaque index, gingival index, and bleeding on probing after 3 and 7 days of rinsing (p≤0.05) but with non-significant differences with chlorhexidine group (p>0.05). It had significant effect in reduction of interleukine-1β which begin after one day of rinsing and continued into three days (p≤0.05).

Conclusions: Punica like chlorhexidine has a positive effect on reduction of plaque accumulation and improvement of gingival inflammation so can be used as an anti-plaque and anti-inflammatory agent in the treatment of gingival inflammation.                                                                                          

                                                                                                                                                                                                                                                                                                                                                      Full Article - PDF

Keywords: Punica Granatum, Gingivitis, Chlorhexidine, Mouthwash, Interleukine-1β.

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