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Effect of Periodontal Therapy on Salivary Total Protein, TNF-alpha and IL-1 beta in Chronic Periodontitis Patients 

* Chenar A. Mohammad

* Department of Periodontics, College of Dentistry, Hawler Medical University, Erbil, Iraq.

Submitted: 14/02/2018; Accepted: 02/05/2018; Published 31/08/2018



Objective: Periodontitis is a chronic infectious inflammatory disease of tissues surrounding and supporting the teeth, it causes by microbial plaque accumulation and its severity depend on interaction between pathogenic bacteria
and host immune response. This study aimed to evaluate the effect of scaling and root planning on the mean values of salivary total protein (TP), tumor necrosis factor-alpha (TNF-α) and interleukin 1 beta (IL-1β).

Methods: Comparative study conducted on 40 volunteers: 20 of them with chronic periodontitis and 20 with healthy periodontium. Scaling and root planning was conducted for chronic periodontitis patients and unstimulated
saliva was collected from all studied subjects at baseline before and after 4 weeks of periodontal treatment to estimate the mean levels of TP, TNF-α and IL-1β.

Results:  High mean values of clinical periodontal inflammatory parameters (plaque index, gingival index, probing pocket depth and clinical attachment loss), TP, TNF-α and IL-1β were detected in chronic periodontitis patients as compared to controls (p<0.000), and significant reduction in their mean values were seen after 4 weeks of periodontal therapy as compared to baseline before treatment (p<0.000).

Conclusions: Biochemical (TP) and immunological parameters (TNF-α and IL-1β) detected at increased levels in chronic periodontitis patients and reduced after periodontal therapy, so further studies are necessary to evaluate the diagnostic and prognostic values of these markers.


Keywords: Total protein, TNF-α, IL-1β, Chronic periodontitis.


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