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Evaluation of Salivary Biomarkers and Their Correlation to Periodontal Status and BMI

Tarza J. Mahmood* , Faraedon M. Zardawi*

*Department of Periodontics, College of Dentistry, Sulaimani University, Sulaimani, Iraq.

Submitted: 01/09/2020; Accepted: 10/09/2020; Published 01/12/2020



Objective: This study aimed to determine the correlation between periodontal status and BMI by evaluating salivary biomarkers - Resistin, visfatin, and TNF-α.          

Methods: Among 580 screened subjects, 86 subjects (30 male and 56 female) aged 30-60 years recruited and grouped into four groups, Group 1 – non-obese with healthy periodontium, group 2 – non-obese with periodontitis, group 3 - obese with healthy periodontium, and group 4 - obese with periodontitis, according to their clinical periodontal parameters and BMI. (ELISA) was used to measure the salivary concentration of Resistin, Visfatin, and TNF-α. (SPSS, v.20.0) applied for statistical analysis, Shapiro-Wilk used to test the Normality of distribution. One-way ANOVA and Mann-Whitney U test were used to analyze the outcome data.

Results: Significant differences in the clinical variables (PI, BI, PPD, and CAL) between test and control groups, with and with no periodontitis (P<0.05). However, no significant differences (P>0.05) between the level of Resistin were detected in the four groups tested. TNF-α was and periodontitis obese groups (P-value< 0.05). No significant correlations were found between clinical periodontal parameters and BMI and the three biomarkers' levels in the four groups tested in this study.

Conclusions: The study failed to detect significant positive correlations between the salivary biomarkers' levels and clinical periodontal and obesity parameters.


Keywords: BMI, Obesity, Periodontitis, Salivary biomarker.                                                                                                                                                                                                                                                Full Article - PDF                                                                                                                                                                                                                                   


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