Evaluation of the Effect of Nitrofurantoin Paste as an Intracanal Medicament on the Chemical Structure of Radicular Dentine

Volume 8 , Issue 2 , December 2021 , Pages 26-33

Authors

Mewan S. Abdulrahman 1 ; Bestoon M. Faraj 1 ; Kawa F. Dizaye 2

1 Department of Conservative Dentistry, College of Dentistry, University of Sulaimani, Sulaimani, Iraq.

2 Department of Basic Sciences, College of Medicine, Hawler Medical University, Erbil, Iraq.

DOI logo 10.17656/sdj.10137

Keywords

Abstract

Objective: To investigate the effects of a new intracanal medicament (nitrofurantoin paste) on radicular dentin's chemical structure compared with modified triple antibiotic paste (MTAP).  

Methods: A total of 9 extracted human maxillary canine teeth were used. After cutting the crowns, the root length was standardized to 15 mm. Three 5 mm root cylinders (coronal, middle, and apical) thirds were obtained. Each cylinder was then sectioned longitudinally across the root canal's maximum diameter, resulting in six half-root specimens; two coronal halves, two middle halves, and two apical halves. Then each specimen was divided into three groups. Group 1: 25mg/mL Nit paste, Group 2: 25mg/mL MTAP, and Group 3: (Untreated). Fourier transform infrared spectrophotometer (FTIR) with a diamond attenuated total reflectance (ATR) accessory was used to obtain infrared spectra to analyze dentin specimens. The data were analyzed statistically using one-way ANOVA and Tukey test, and significant differences were used for statistical analyses.     

Results: Dentin thirds treated with MTAP had a lower phosphate/amide I ratio (p < 0.05) than Nit paste compared with the untreated group. Moreover, the phosphate/amide I ratio was highest in the apical third and decreased to the lowest value in the coronal third. The differences among all three-thirds were statistically significant.

Conclusions: According to the current study results, at the concentration of (25 mg/mL), nitrofurantoin paste minimizes the reduction of phosphate/amide I ratio of the radicular dentine compared with the 25mg/mL MTAP. 

Statistics
  • Article view770
  • Downloads5
  • Published at1 December 2021

  • RIS
  • BibTeX
  • EndNote
  • Mendeley
  • APA (7th edition)
  • MLA (9th edition)
  • Chicago
  • Harvard
  • IEEE
  • Vancouver