Effect of Periodontal Therapy on Salivary Total Protein, TNF-alpha and IL-1 beta in Chronic Periodontitis Patients

Volume 5 , Issue 1 , August 2018 , Pages 16-23

Authors

Chenar A. Mohammad 1

1 Department of Periodontology /Hawler Medical University /College of Dentistry, Erbil, Iraq.

DOI logo 10.17656/sdj.10072

Keywords

Abstract

Objective: Periodontitis is a chronic infectious disease of tissues surrounding and supporting the teeth, it causes by microbial plaque
accumulation and its severity depend on interaction between pathogenic bacteria and host immune response. This study aimed to evaluate
the effect of scaling and root planing on the mean values of salivary total protein (TP), tumor necrosis factor-alpha (TNF-α) and
interleukin 1 beta (IL-1β).
Methods: Comparative study conducted on 40 volunteers: 20 of them with chronic periodontitis and 20 with healthy periodontium.
Scaling and root planing was conducted for chronic periodontitis patients and unstimulated saliva was collected from all studied subjects
at baseline before and after 4 weeks of periodontal treatment to estimate the mean levels of TP, TNF-α and IL-1β.
Results: High mean values of clinical periodontal parameters (plaque index, gingival index, probing pocket depth and clinical attachment
loss), TP, TNF-α and IL-1β were detected in chronic periodontitis patients as compared to controls (p<0.000), and significant reduction in
their mean values were seen after 4 weeks of periodontal therapy as compared to base line before treatment (p<0.000).
Conclusions: Biochemical (TP) and immunological parameters (TNF-α and IL-1β) detected at increased levels in chronic periodontitis
patients and reduced after periodontal therapy, so further studies are necessary to evaluate the diagnostic and prognostic values of these
markers. 

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  • Published at1 August 2018

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