Immunohistochemical expression of P-cadherin and cortactin in oral squamous cell carcinomas

Volume 2 , Issue 1 , June 2015 , Pages 8-14

Authors

Dena N. Mohammad 1 ; Balkees T. Garib 2 ; Hassanain H. Khudeir 3 ; Ban A Abdul–Majeed 4

1 B.D.S, M.Sc, Ph.D. (Oral Pathology). Lecturer at Department of Oral Diagnosis. School of Dentistry - Faculty of Medical Sciences/ University of Sulaimani.

2 B.D.S, M.Sc, Ph.D. (Oral Pathology). Professor at Department of Oral Diagnosis. School of Dentistry - Faculty of Medical Sciences/ University of Sulaimani.

3 M.B.Ch.B, FICMS. School of Medicine - Faculty of Medical Sciences / University of Sulaimani.

4 B.D.S, M.Sc, Ph.D. (Oral Pathology). College of Medicine, University of Baghdad. Baghdad, Iraq.

DOI logo 10.17656/sdj.10030

Keywords

Abstract

Objectives: to assess the expression and pattern distribution of P-cadherin and cortactin in OSCC, and to relate such expression to the histopathological grading.

Materials and Methods: An immunohistochemical staining for P-cadherin and cortactin was performed on paraffin blocks of 40 oral squamous cell carcinoma and five normal mucosa. Fisher's exact test and Spearman's rank-order correlation were applied for analysis. P < 0.05 was considered statistically significant.

Results: P-cadherin was either aberrantly cytoplasmic re-localized or lost in 45% of cases. 58.6% of positive cases were in grade I. Focal heterogeneous pattern was the commonest pattern (27.5%) and related to the degree of cell differentiation. The expression percentage was reported mainly in score 1 and 2 with no differences among histopathological grades (P=0.778). On the other hand, 70% of oral SCC had cytoplasmic cortactin expression. The majority of cases (85.7%) expressed diffuse pattern including all positive grade II and III cases. Nevertheless, statistical analysis did not reach a significant level (P= 0.722). Furthermore, no significant correlation was found between P-cadherin and cortactin expression.

Conclusion: Oral SCC had P-cadherin under-expression (focal) and cortactin over-expression (diffuse). The P-cadherin pattern distribution rather than expression percentage was related to the degree of cell differentiation. The expressions of these molecules were unrelated to each other.

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  • Published at1 June 2015

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